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CS-W001157 4
Total: USD 88.00

Methyl 6-(trifluoromethyl)nicotinate

  • CAS No. 221313-10-6

  • Cat. No. CS-W015385
  • Molecule weight205.13
  • Purity≥98%
  • MDL No.MFCD03001346

*For research and further manufacturing use only, not for direct human use.

Methyl 6-(trifluoromethyl)nicotinate|CS-W015385

Structure of 221313-10-6

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General Information

  • CAS No. 221313-10-6
  • Cat. No. CS-W015385
  • Purity ≥98%
  • MDL No. MFCD03001346
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆F₃NO₂
  • Molecular Weight 205.13
  • Synonym(s) METHYL6-(TRIFLUOROMETHYL)NICOTINATE
  • SMILES O=C(OC)C1=CN=C(C(F)(F)F)C=C1

Description

2-Bromo-4-fluorobenzylamine hydrochloride used as a intermediate in pharmaceutical.

Application

Methyl 6-(trifluoromethyl)nicotinate serves as a versatile building block in medicinal chemistry, enabling efficient access to trifluoromethylated heterocycles. Its electron-deficient pyridine core facilitates nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions. The methyl ester group offers straightforward derivatization, while the trifluoromethyl moiety imparts enhanced metabolic stability and lipophilicity—key attributes for drug discovery. Bench-stable and readily purified, it functions reliably in standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.887
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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