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CS-W001157 4
Total: USD 88.00

Methyl 2-(thiophen-2-yl)acetate

  • CAS No. 19432-68-9

  • Cat. No. CS-0042494
  • Purity≥95%
  • MDL No.MFCD00041213

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(thiophen-2-yl)acetate|CS-0042494

Structure of 19432-68-9

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General Information

  • CAS No. 19432-68-9
  • Cat. No. CS-0042494
  • Purity ≥95%
  • MDL No. MFCD00041213
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈O₂S
  • Molecular Weight 156.20
  • Synonym(s) Methyl 2-Thiopheneacetate
  • SMILES O=C(OC)CC1=CC=CS1

Description

Methyl 2-(thiophen-2-yl)acetate features a thiophene ring directly linked to a carbonyl-bearing methyl ester, enabling seamless integration into heterocyclic synthesis. This bench-stable, moisture-tolerant reagent serves as a key building block for functionalized thienyl compounds in pharmaceutical and materials development.

Application

Methyl 2-(thiophen-2-yl)acetate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to thiophene-containing scaffolds via Pd-catalyzed cross-coupling and functional group transformation. Its α-ester functionality facilitates nucleophilic addition and enolate chemistry, while the thiophene ring provides robust stability and orthogonal reactivity. The compound exhibits excellent bench stability and ease of purification, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      67-56-1
    • 2-Thiopheneacetic acid Cefoxitin  Impurity|CS-0229338
      1918-77-0
    • ~99%
    • In-stock
      Methyl 2-(thiophen-2-yl)acetate|CS-0042494
      19432-68-9

    References

    • Kunes, Jiri; Balsanek, Vojtech; Pour, Milan; Buchta, Vladimir Collection of Czechoslovak Chemical Communications, 2001 , vol. 66, # 12 p. 1809 - 1830
  • Route2
    • In-stock
      2-Acetylthiophene|CS-W020047
      88-15-3
    • null|null
      67-56-1
    • ~88%
    • In-stock
      Methyl 2-(thiophen-2-yl)acetate|CS-0042494
      19432-68-9

    References

    • Huddar, Sameerana N.; Deshmukh, Swapnil S.; Akamanchi, Krishnacharya G. Arkivoc, 2011 , vol. 2011, # 5 p. 67 - 75
  • Route3
    • null|null
      186581-53-3
    • null|null
      5271-67-0
    • ~%
    • In-stock
      Methyl 2-(thiophen-2-yl)acetate|CS-0042494
      19432-68-9

    References

    • Journal of the American Chemical Society, , vol. 63, p. 2945

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.4636
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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