N-(2,4-Dichloropyrimidin-5-yl)acetamide

Name: N-(2,4-Dichloropyrimidin-5-yl)acetamide
Brand: ChemScene
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CAS No. 89581-88-4
Cat. No. CS-0160435
Purity≥97%
MDL No.MFCD24571797

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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N-(2,4-Dichloropyrimidin-5-yl)acetamide|CS-0160435

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General Information

CAS No. 89581-88-4
Cat. No. CS-0160435
Purity ≥97%
MDL No. MFCD24571797
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅Cl₂N₃O
Molecular Weight 206.03
Synonym(s) N-(2,4-Dichloro-5-pyrimidinyl)acetamide
SMILES CC(NC1=CN=C(Cl)N=C1Cl)=O

Description

N-(2,4-Dichloropyrimidin-5-yl)acetamide features a pyrimidine core functionalized with two chlorine atoms at the 2- and 4-positions, enabling strong electron-withdrawing effects. The acetamide group provides a polar, hydrogen-bond-capable handle for coupling reactions. This structure integrates readily into pharmaceutical intermediates and agrochemical scaffolds, offering enhanced metabolic stability and targeted binding affinity in kinase inhibitors and DNA-targeting agents.

Application

N-(2,4-Dichloropyrimidin-5-yl)acetamide serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution and coupling reactions. The dichloropyrimidine core exhibits high reactivity toward amines and thiols, facilitating rapid diversification. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows for API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 54.88
LogP 1.7418
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amide

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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N-(2,4-Dichloropyrimidin-5-yl)acetamide

CAS No. 89581-88-4

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