Lot numbers can be found on the outside label of a product:
3-Bromo-8-chloroimidazo[1,2-a]pyrazine
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CAS No. 143591-61-1
- Cat. No. CS-W019641
- Purity≥97%
- MDL No.MFCD09909653
*For research and further manufacturing use only, not for direct human use.
![3-Bromo-8-chloroimidazo[1,2-a]pyrazine|CS-W019641](https://file.chemscene.com/productPIC/CS-W019641.gif)
Structure of 143591-61-1
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General Information
- CAS No. 143591-61-1
- Cat. No. CS-W019641
- Purity ≥97%
- MDL No. MFCD09909653
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₃BrClN₃
- Molecular Weight 232.47
- Synonym(s) 8-Chloro-3-bromoimidazo[1,2-a]pyrazine
- SMILES ClC1=NC=CN2C1=NC=C2Br
Description
3-Bromo-8-chloroimidazo[1,2-a]pyrazine is a halogenated heterocyclic scaffold featuring complementary electrophilic sites at the 3- and 8-positions. This electron-deficient core enables selective cross-coupling reactions and serves as a key building block in medicinal chemistry. The molecule exhibits good stability under standard conditions and facilitates direct functionalization in late-stage diversification.
Application
3-Bromo-8-chloroimidazo[1,2-a]pyrazine serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. The molecule enables palladium-catalyzed cross-coupling reactions due to its dual halogen functionality, with bromine at C3 offering high reactivity in Suzuki-Miyaura and Buchwald-Hartwig transformations. Its bench-stable nature and orthogonal reactivity profile facilitate efficient diversification of imidazopyrazine scaffolds in multi-step syntheses.
Synthesis
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Route1
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In-stock
![8-Chloroimidazo[1,2-a]pyrazine|CS-W004033](https://file.chemscene.com/productPIC/CS-W004033.gif)
69214-33-1 - ~98%
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In-stock
143591-61-1
References
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BIOFOCUS DPI LIMITED Patent: WO2009/24585 A2, 2009 ; Location in patent: Page/Page column 46 ;
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Route2
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![8-Chloroimidazo[1,2-a]pyrazine hydrobromide|CS-1719385](https://file.chemscene.com/productPIC/CS-1719385.gif)
937790-53-9 - ~90%
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In-stock
143591-61-1
References
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Schering Corporation Patent: US2007/117804 A1, 2007 ; Location in patent: Page/Page column 47 ; US 20070117804 A1
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Route3
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In-stock
69214-33-1
- ~%
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In-stock
143591-61-1
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![3,8-Dibromoimidazo[1,2-a]pyrazine|CS-0085065](https://file.chemscene.com/productPIC/CS-0085065.gif)
936361-36-3
References
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WO2010/69684 A1, ; Page/Page column 97 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 30.19
- LogP 2.1452
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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