Lot numbers can be found on the outside label of a product:
2,6-Dichloro-4-methylpyridine
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CAS No. 39621-00-6
- Cat. No. CS-W003612
- Purity≥98%
- MDL No.MFCD09264302
*For research and further manufacturing use only, not for direct human use.
Structure of 39621-00-6
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General Information
- CAS No. 39621-00-6
- Cat. No. CS-W003612
- Purity ≥98%
- MDL No. MFCD09264302
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₅Cl₂N
- Molecular Weight 162.02
- Synonym(s) 6-Dichloro-4-picoline
- SMILES Cc1cc(Cl)nc(c1)Cl
Description
2,6-Dichloro-4-methylpyridine is a chlorinated pyridine derivative featuring two chlorine substituents at the 2 and 6 positions and a methyl group at the 4 position. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct functionalization at the 3 and 5 ring positions via cross-coupling reactions. Its bench-stable nature and compatibility with palladium-catalyzed transformations streamline synthesis of complex pharmaceutical intermediates.
Application
2,6-Dichloro-4-methylpyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of nitrogen-containing heterocycles. Its electrophilic C2 and C6 positions facilitate palladium-catalyzed cross-coupling reactions, while the methyl group provides a site for oxidation or functionalization. The compound exhibits good bench stability and compatibility with common protecting groups, making it suitable for multi-step synthetic sequences.
Synthesis
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References
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ACTELION PHARMACEUTICALS LTD Patent: WO2009/24905 A1, 2009 ; Location in patent: Page/Page column 73 ; WO 2009/024905 A1
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Route2
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In-stock
98027-84-0 -
823-96-1 - ~%
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In-stock
39621-00-6
References
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NIPPON SHINYAKU CO., LTD. Patent: US2011/288065 A1, 2011 ; Location in patent: Page/Page column 46 ; US 20110288065 A1
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Route3
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52313-61-8
- ~42%
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In-stock
39621-00-6
References
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F2G LIMITED Patent: US2011/9390 A1, 2011 ; Location in patent: Page/Page column 19 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 12.89
- LogP 2.69682
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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