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CS-W001157 4
Total: USD 88.00

2,6-Dichloroisonicotinonitrile

  • CAS No. 32710-65-9

  • Cat. No. CS-W001246
  • Purity≥98%
  • MDL No.MFCD00173784

*For research and further manufacturing use only, not for direct human use.

2,6-Dichloroisonicotinonitrile|CS-W001246

Structure of 32710-65-9

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General Information

  • CAS No. 32710-65-9
  • Cat. No. CS-W001246
  • Purity ≥98%
  • MDL No. MFCD00173784
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂Cl₂N₂
  • Molecular Weight 173.00
  • Synonym(s) 4-Pyridinecarbonitrile, 2,6-dichloro-
  • SMILES N#Cc1cc(Cl)nc(c1)Cl

Description

2,6-Dichloroisonicotinonitrile features a rigid pyridine core bearing electron-withdrawing chlorine substituents at the 2 and 6 positions and a nitrile group at the 3 position. This configuration imparts high electrophilicity and stability under standard conditions, enabling its use in coupling reactions and as a building block for heterocyclic synthesis.

Application

2,6-Dichloroisonicotinonitrile serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted pyridine scaffolds via nucleophilic aromatic substitution. Its dual chloro groups facilitate sequential functionalization, while the nitrile moiety offers compatibility with standard transformations such as hydrolysis or reduction. Bench-stable and readily purified, it functions effectively in multi-step syntheses requiring precise regiocontrol and functional group tolerance.

Synthesis

  • Route1
    • null|null
      557-21-1
    • In-stock
      2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine|CS-W010088
      408492-27-3
    • ~%
    • In-stock
      2,6-Dichloroisonicotinonitrile|CS-W001246
      32710-65-9

    References

    • Liskey, Carl W.; Liao, Xuebin; Hartwig, John F. Journal of the American Chemical Society, 2010 , vol. 132, # 33 p. 11389 - 11391
  • Route2

    References

    • Recueil des Travaux Chimiques des Pays-Bas, , vol. 48, p. 468,471
  • Route3

    References

    • Recueil des Travaux Chimiques des Pays-Bas, , vol. 48, p. 468,471

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   2.26008
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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