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CS-W001157 4
Total: USD 88.00

4,6-Dichloropicolinic acid

  • CAS No. 88912-25-8

  • Cat. No. CS-W018783
  • Purity≥97%
  • MDL No.MFCD09910267

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloropicolinic acid|CS-W018783

Structure of 88912-25-8

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General Information

  • CAS No. 88912-25-8
  • Cat. No. CS-W018783
  • Purity ≥97%
  • MDL No. MFCD09910267
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃Cl₂NO₂
  • Molecular Weight 192.00
  • Synonym(s) 4,6-Dichloropyridine-2-carboxylic acid
  • SMILES ClC1=CC(=NC(=C1)C(=O)O)Cl

Description

4,6-Dichloropicolinic acid is a bench-stable, electron-deficient heterocyclic carboxylic acid featuring two chlorine substituents at the 4- and 6-positions of the pyridine ring. This configuration enhances its utility in transition metal-catalyzed coupling reactions and as a building block for bioactive heterocycles. The molecule integrates readily into pharmaceutical scaffolds due to its polar, rigid framework and favorable reactivity profile under standard conditions.

Application

4,6-Dichloropicolinic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via cyclization or coupling reactions. Its dual chlorine substituents enhance electrophilicity at the pyridine ring, facilitating nucleophilic substitution and transition-metal-catalyzed functionalization. The carboxylic acid group provides a handle for derivatization, including amide formation and esterification, while the compound exhibits good bench stability and ease of purification—key attributes for scalable synthesis and process development.

Synthesis

  • Route1

    References

    • Kureha Kagaku Kogyo K.K. Patent: US6610853 B1, 2003 ;
  • Route2
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      98138-06-8
    • ~%
    • In-stock
      4,6-Dichloropicolinic acid|CS-W018783
      88912-25-8

    References

    • Journal of Organic Chemistry, , vol. 23, p. 1030
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 23, p. 1030

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.0866
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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