(4,6-Dichloropyridin-2-yl)methanol

Name: (4,6-Dichloropyridin-2-yl)methanol
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CAS No. 856163-79-6
Cat. No. CS-0158297
Purity≥98%
MDL No.MFCD26517849

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(4,6-Dichloropyridin-2-yl)methanol|CS-0158297

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General Information

CAS No. 856163-79-6
Cat. No. CS-0158297
Purity ≥98%
MDL No. MFCD26517849
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅Cl₂NO
Molecular Weight 178.02
Synonym(s) (4,6-Dichloro-2-pyridinyl)methanol
SMILES C(O)C=1C=C(C=C(N1)Cl)Cl

Description

This bench-stable, moisture-tolerant pyridylmethanol features a dual chloro substitution that enhances electrophilic reactivity. The functional group integrates readily into coupling reactions, serving as a key intermediate in the synthesis of pharmaceuticals and agrochemicals.

Application

(4,6-Dichloropyridin-2-yl)methanol serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds and functionalized intermediates. Its dichloropyridine core provides high reactivity in nucleophilic substitution reactions, particularly with amines and thiols, facilitating the rapid assembly of complex molecules. The benzylic alcohol functionality offers a handle for selective derivatization, including oxidation or protection, while maintaining compatibility with diverse reaction conditions. Bench-stable and readily purified by distillation or chromatography, it functions reliably in both small-scale synthesis and process development workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 33.12
LogP 1.8807
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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(4,6-Dichloropyridin-2-yl)methanol

CAS No. 856163-79-6

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