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CS-W001157 4
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3,3'-Dimethoxy-[1,1'-biphenyl]-4,4'-dicarbaldehyde

  • CAS No. 27343-98-2

  • Cat. No. CS-0166725
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3,3'-Dimethoxy-[1,1'-biphenyl]-4,4'-dicarbaldehyde|CS-0166725

Structure of 27343-98-2

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General Information

  • CAS No. 27343-98-2
  • Cat. No. CS-0166725
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₄O₄
  • Molecular Weight 270.28
  • Synonym(s) None
  • SMILES O=CC1=C(OC)C=C(C2=CC=C(C(OC)=C2)C=O)C=C1

Description

This 3,3'-dimethoxy-[1,1'-biphenyl]-4,4'-dicarbaldehyde features two electron-rich methoxy groups flanking a rigid biphenyl core, delivering enhanced solubility and stability. The dual aldehyde functionalities enable efficient coupling in Suzuki-Miyaura or reductive amination workflows, facilitating the synthesis of complex biaryl architectures with precise spatial control.

Application

3,3'-Dimethoxy-[1,1'-biphenyl]-4,4'-dicarbaldehyde serves as a versatile bifunctional building block for the synthesis of functionalized biaryls and heterocyclic scaffolds. The ortho-dimethoxy substitution pattern enhances solubility and stability, while the paired aldehyde groups enable efficient coupling reactions, including reductive amination and Wittig transformations. Its robust bench stability and compatibility with standard purification methods make it well-suited for iterative synthesis in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   2.9958
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   5

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