6-Chloro-4-fluoro-1H-indole

Name: 6-Chloro-4-fluoro-1H-indole
Brand: ChemScene
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CAS No. 885520-88-7
Cat. No. CS-0050224
Purity≥98%
MDL No.MFCD07781560

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 885520-88-7
Cat. No. CS-0050224
Purity ≥98%
MDL No. MFCD07781560
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅ClFN
Molecular Weight None
Synonym(s) 6-Chloro-4-fluoro indole
SMILES FC1=CC(Cl)=CC2=C1C=CN2

Description

6-Chloro-4-fluoro-1H-indole is a fluorinated indole scaffold featuring orthogonal halogen substituents at the 6- and 4-positions, enabling selective functionalization in medicinal chemistry. This electron-deficient heterocycle integrates readily into bioactive molecules, offering enhanced metabolic stability and improved binding affinity in target-directed drug discovery.

Application

6-Chloro-4-fluoro-1H-indole serves as a valuable building block in medicinal chemistry, enabling direct functionalization at the C3 position via palladium-catalyzed cross-coupling. Its electron-deficient aromatic core enhances reactivity in Suzuki-Miyaura and Buchwald-Hartwig reactions, while the halogen substituents provide orthogonal handles for sequential derivatization. Bench-stable and readily purified by column chromatography, it facilitates efficient access to diverse indole-based scaffolds relevant to kinase inhibitors and CNS-targeted therapeutics.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 15.79
LogP 2.9604
H_Acceptors 0
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Indole compounds

Key Words

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6-Chloro-4-fluoro-1H-indole

CAS No. 885520-88-7

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