5-Chloro-4-fluoro-1H-indole

Name: 5-Chloro-4-fluoro-1H-indole
Brand: ChemScene
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CAS No. 376646-56-9
Cat. No. CS-W022355
Purity≥97%
MDL No.MFCD01074494

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 376646-56-9
Cat. No. CS-W022355
Purity ≥97%
MDL No. MFCD01074494
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅ClFN
Molecular Weight 169.59
Synonym(s) 5-CHLORO-4-FLUOROINDOLE
SMILES FC1=C(Cl)C=CC2=C1C=CN2

Description

5-Chloro-4-fluoro-1H-indole is a fluorinated indole scaffold featuring orthogonal halogen substituents at the 4- and 5-positions, enabling selective functionalization in late-stage diversification. This electron-deficient core integrates readily into bioactive molecule architectures, particularly in kinase inhibitors and CNS-targeted therapeutics.

Application

5-Chloro-4-fluoro-1H-indole serves as a valuable building block for pharmaceutical and agrochemical synthesis, offering enhanced electronic properties through orthogonal halogen substitution. Its stability under standard reaction conditions enables reliable use in Pd-catalyzed cross-couplings, while the fluorine and chlorine substituents provide strategic handles for further functionalization. The molecule functions effectively in heterocyclic scaffold construction and demonstrates good solubility and ease of purification in routine synthetic workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 15.79
LogP 2.9604
H_Acceptors 0
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Indole compounds

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5-Chloro-4-fluoro-1H-indole

CAS No. 376646-56-9

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