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CS-W001157 4
Total: USD 88.00

2-(6-Chloropyridin-2-yl)acetic acid

  • CAS No. 885267-14-1

  • Cat. No. CS-0149601
  • Purity≥97%
  • MDL No.MFCD08706288

*For research and further manufacturing use only, not for direct human use.

2-(6-Chloropyridin-2-yl)acetic acid|CS-0149601

Structure of 885267-14-1

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General Information

  • CAS No. 885267-14-1
  • Cat. No. CS-0149601
  • Purity ≥97%
  • MDL No. MFCD08706288
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₂
  • Molecular Weight 171.58
  • Synonym(s) 2-(6-Chloropyridin-2-yl)
  • SMILES O=C(O)CC1=NC(Cl)=CC=C1

Description

2-(6-Chloropyridin-2-yl)acetic acid features a chlorinated pyridine ring linked to a carboxylic acid-bearing side chain, enabling direct integration into bioactive molecule scaffolds. This moiety imparts enhanced metabolic stability and targeted electronic properties, facilitating efficient coupling in pharmaceutical synthesis workflows under standard conditions.

Application

2-(6-Chloropyridin-2-yl)acetic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-containing scaffolds via standard coupling reactions. Its functional group tolerance and bench stability facilitate straightforward derivatization, including amide formation and esterification, supporting rapid analog synthesis for target-directed discovery campaigns.

Synthesis

  • Route1
    • In-stock
      2-Chloro-6-methylpyridine|CS-W001993
      18368-63-3
    • null|null
      124-38-9
    • ~%
    • In-stock
      2-(6-Chloropyridin-2-yl)acetic acid|CS-0149601
      885267-14-1

    References

    • Tetrahedron, , vol. 51, # 5 p. 1337 - 1344
  • Route2
    • In-stock
      2-Chloro-6-hydrazinopyridine|CS-W021667
      5193-03-3
    • null|null
      75-36-5
    • ~%
    • In-stock
      2-(6-Chloropyridin-2-yl)acetic acid|CS-0149601
      885267-14-1

    References

    • US4260767 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.3621
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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