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CS-W001157 4
Total: USD 88.00

2-Chloro-6-methylpyridine

  • CAS No. 18368-63-3

  • Cat. No. CS-W001993
  • Purity≥97%
  • MDL No.MFCD00006245

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-methylpyridine|CS-W001993

Structure of 18368-63-3

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General Information

  • CAS No. 18368-63-3
  • Cat. No. CS-W001993
  • Purity ≥97%
  • MDL No. MFCD00006245
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClN
  • Molecular Weight 127.57
  • Synonym(s) 6-Chloro-2-picoline
  • SMILES CC1=NC(Cl)=CC=C1

Description

2-Chloro-6-methylpyridine is a bench-stable, electron-deficient heterocycle featuring a chlorine atom at the 2-position and a methyl group at the 6-position. This regioselective substitution pattern enables direct functionalization in cross-coupling reactions, facilitating efficient access to complex pyridyl architectures in medicinal chemistry and agrochemical synthesis.

Application

2-Chloro-6-methylpyridine serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity at the chlorine site. The methyl group provides a handle for further functionalization, while the pyridine core offers favorable electronic properties for heterocyclic scaffold construction. Its bench stability and compatibility with standard reaction conditions make it a reliable choice for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, , vol. 50, p. 536 Chem. Zentralbl., , vol. 94, # III p. 1022
  • Route2

    References

    • Lai, Long-Li; Lin, Pen-Yuan; Wang, Jy-Shih; Hwu, Jih Ru; Shiao, Min-Jen; Tsay, Shwu-Chen Journal of Chemical Research - Part S, 1996 , # 4 p. 194 - 195
  • Route3
    • null|null
      107622-87-7
    • ~69%
    • In-stock
      2-Chloro-6-methylpyridine|CS-W001993
      18368-63-3

    References

    • Lai, Long-Li; Lin, Pen-Yuan; Wang, Jy-Shih; Hwu, Jih Ru; Shiao, Min-Jen; Tsay, Shwu-Chen Journal of Chemical Research - Part S, 1996 , # 4 p. 194 - 195

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.04342
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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