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Structure of 914950-09-7
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2-Chloro-6-ethynylpyridine features a conjugated alkyne tethered to a chloropyridine core, enabling direct incorporation into CuAAC click chemistry workflows. The electron-deficient pyridine ring enhances reactivity in transition-metal-catalyzed couplings, while the terminal alkyne offers high functional group tolerance and compatibility with diverse nucleophiles under standard conditions.
2-Chloro-6-ethynylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to install aryl or heteroaryl extensions. The ortho-chloropyridine functionality offers directed metallation and compatibility with Suzuki, Stille, and Sonogashira protocols. Its ethynyl group facilitates further functionalization via click chemistry or cyclization cascades, while the pyridine ring provides favorable solubility and stability under standard reaction conditions.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302+H312+H332-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: