Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2,4-Dichloro-6-methylpyridine

  • CAS No. 42779-56-6

  • Cat. No. CS-W003538
  • Purity≥97%
  • MDL No.MFCD08669834

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-6-methylpyridine|CS-W003538

Structure of 42779-56-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 42779-56-6
  • Cat. No. CS-W003538
  • Purity ≥97%
  • MDL No. MFCD08669834
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅Cl₂N
  • Molecular Weight 162.02
  • Synonym(s) 2,4-Dichloro-6-Picoline
  • SMILES CC1=CC(Cl)=CC(Cl)=N1

Description

2,4-Dichloro-6-methylpyridine serves as a key heterocyclic scaffold in medicinal chemistry and agrochemical synthesis. The electron-deficient pyridine ring, flanked by two chlorine substituents and a methyl group at the 6-position, enables selective coupling reactions. This configuration enhances reactivity in cross-coupling processes while maintaining stability under standard reaction conditions.

Application

2,4-Dichloro-6-methylpyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling selective functionalization at the 3- and 5-positions via palladium-catalyzed cross-coupling. Its ortho-chlorine atoms exhibit high reactivity in nucleophilic substitution reactions, while the methyl group provides a stable handle for further derivatization. The compound demonstrates excellent bench stability and compatibility with standard purification methods, facilitating efficient incorporation into complex heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1

    References

    • Dahlgren, Markus K.; Garcia, Alvaro Baeza; Hare, Alissa A.; Tirado-Rives, Julian; Leng, Lin; Bucala, Richard; Jorgensen, William L. Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10148 - 10159
  • Route2
    • null|null
      1314934-13-8
    • ~%
    • In-stock
      2,4-Dichloro-6-methylpyridine|CS-W003538
      42779-56-6

    References

    • Di Fabio, Romano; Arban, Roberto; Bernasconi, Giovanni; Braggio, Simone; Blaney, Frank E.; Capelli, Anna M.; Castiglioni, Emiliano; Donati, Daniele; Fazzolari, Elettra; Ratti, Emiliangelo; Feriani, Aldo; Contini, Stefania; Gentile, Gabriella; Ghirlanda, Damiano; Sabbatini, Fabio M.; Andreotti, Daniele; Spada, Simone; Marchioro, Carla; Worby, Angela; St-Denis, Yves Journal of Medicinal Chemistry, 2008 , vol. 51, # 22 p. 7273 - 7286
  • Route3
    • In-stock
      6-Methylpyridine-2,4-diol|CS-W002835
      3749-51-7
    • null|null
      10025-87-3
    • ~%
    • In-stock
      2,4-Dichloro-6-methylpyridine|CS-W003538
      42779-56-6

    References

    • Collie; Myers Journal of the Chemical Society, 1892 , vol. 61, p. 726 Full Text Show Details Sedgwick; Collie Journal of the Chemical Society, 1895 , vol. 67, p. 408

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.69682
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2,4-Dichloro-6-methylpyridine sigma2,4-Dichloro-6-methylpyridine manufacturer2,4-Dichloro-6-methylpyridine price2,4-Dichloro-6-methylpyridine structure2,4-Dichloro-6-methylpyridine SDSbuy 2,4-Dichloro-6-methylpyridine2,4-Dichloro-6-methylpyridine supplier2,4-Dichloro-6-methylpyridine uses2,4-Dichloro-6-methylpyridine molecular weightprice of 2,4-Dichloro-6-methylpyridine2,4-Dichloro-6-methylpyridine chemical name formula of 2,4-Dichloro-6-methylpyridine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label