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CS-W001157 4
Total: USD 88.00

6-Methylpyridine-2,4-diol

  • CAS No. 3749-51-7

  • Cat. No. CS-W002835
  • Purity≥96%
  • MDL No.MFCD01860849

*For research and further manufacturing use only, not for direct human use.

6-Methylpyridine-2,4-diol|CS-W002835

Structure of 3749-51-7

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General Information

  • CAS No. 3749-51-7
  • Cat. No. CS-W002835
  • Purity ≥96%
  • MDL No. MFCD01860849
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₂
  • Molecular Weight 125.13
  • Synonym(s) 6-Methyl-2,4-pyridinediol
  • SMILES Oc1cc(C)nc(c1)O

Description

4-Hydroxy-6-methylpyridin-2(1H)-one features a pyridinone core with strategically positioned hydroxyl and methyl groups, enabling robust coordination to metal ions. This scaffold delivers enhanced solubility and stability under physiological conditions, facilitating its use in chelation chemistry and as a building block for bioactive heterocycles.

Application

4-Hydroxy-6-methylpyridin-2(1H)-one serves as a versatile heterocyclic building block in medicinal chemistry, offering a stable platform for derivatization via its phenolic hydroxyl and pyridonic nitrogen. Its ortho-dicarbonyl-like reactivity facilitates metal coordination and enables straightforward functionalization for scaffold diversification. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for use in iterative synthesis campaigns targeting bioactive molecules.

Synthesis

  • Route1

    References

    • WO2006/35967 A1, ; Page/Page column 71 ; WO 2006/035967 A1
  • Route2
    • null|null
      67-64-1
    • null|null
      100-46-9
    • ~%
    • In-stock
      6-Methylpyridine-2,4-diol|CS-W002835
      3749-51-7

    References

    • WO2011/22692 A2, ; Page/Page column 22 ; WO 2011/022692 A2
  • Route3

    References

    • Recueil des Travaux Chimiques des Pays-Bas, , vol. 68, p. 1013,1024

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   0.38892
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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