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CS-W001157 4
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Methyl 2-(6-chloropyridin-2-yl)acetate

  • CAS No. 161807-18-7

  • Cat. No. CS-W019003
  • Molecule weight185.61
  • Purity≥97%
  • MDL No.MFCD09834576

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(6-chloropyridin-2-yl)acetate|CS-W019003

Structure of 161807-18-7

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General Information

  • CAS No. 161807-18-7
  • Cat. No. CS-W019003
  • Purity ≥97%
  • MDL No. MFCD09834576
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈ClNO₂
  • Molecular Weight 185.61
  • Synonym(s) Methyl 2-(6-chloropyridin-2-yl)
  • SMILES O=C(OC)CC1=NC(Cl)=CC=C1

Application

Methyl 2-(6-chloropyridin-2-yl)acetate serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-containing scaffolds via standard functional group transformations. Its chloropyridine moiety facilitates palladium-catalyzed cross-coupling reactions, while the ester group supports selective reduction or hydrolysis for downstream derivatization. The compound exhibits excellent bench stability and ease of purification, making it well-suited for scalable synthesis and process development workflows.

Synthesis

  • Route1
    • In-stock
      2-Chloro-6-methylpyridine|CS-W001993
      18368-63-3
    • null|null
      616-38-6
    • ~%
    • In-stock
      Methyl 2-(6-chloropyridin-2-yl)acetate|CS-W019003
      161807-18-7

    References

    • INCEPTION 2, INC.; STOCK, Nicholas, Simon; CHEN, Austin, Chih-Yu; BRAVO, Yalda, Mostofi; JACINTHO, Jason, Duarte; SCOTT, Jill, Melissa; STEARNS, Brian, Andrew; CLARK, Ryan, Christopher; TRUONG, Yen, Pham Patent: WO2013/134562 A1, 2013 ; Location in patent: Paragraph 00202 ;
  • Route2
    • null|null
      67-56-1
    • In-stock
      2-(6-Chloropyridin-2-yl)acetic acid|CS-0149601
      885267-14-1
    • ~%
    • In-stock
      Methyl 2-(6-chloropyridin-2-yl)acetate|CS-W019003
      161807-18-7

    References

    • Davies; Townsend Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6595 - 6603
  • Route3
    • null|null
      67-56-1
    • In-stock
      2-(6-Chloropyridin-2-yl)acetonitrile|CS-0161746
      75279-60-6
    • ~%
    • In-stock
      Methyl 2-(6-chloropyridin-2-yl)acetate|CS-W019003
      161807-18-7

    References

    • Astellas Pharma Inc. Patent: EP1995243 A1, 2008 ; Location in patent: Page/Page column 18 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.4505
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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