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CS-W001157 4
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5-Fluoro-2-oxo-1,2-dihydropyridine-3-carboxylic acid

  • CAS No. 884494-83-1

  • Cat. No. CS-0029878
  • Purity≥98%
  • MDL No.MFCD04972400

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-oxo-1,2-dihydropyridine-3-carboxylic acid|CS-0029878

Structure of 884494-83-1

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General Information

  • CAS No. 884494-83-1
  • Cat. No. CS-0029878
  • Purity ≥98%
  • MDL No. MFCD04972400
  • Storage 4°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO₃
  • Molecular Weight 157.10
  • Synonym(s) 5-Fluoro-2-hydroxynicotinic acid
  • SMILES O=C(C1=CC(F)=CNC1=O)O

Description

5-Fluoro-2-oxo-1,2-dihydropyridine-3-carboxylic acid features a fluorinated pyridine core with orthogonal functional groups enabling direct integration into bioactive scaffolds. The electron-deficient dihydropyridinone ring pairs with the carboxylic acid for efficient coupling reactions, while the fluorine substituent enhances metabolic stability and modulates electronic properties in synthetic intermediates.

Application

5-Fluoro-2-oxo-1,2-dihydropyridine-3-carboxylic acid serves as a versatile building block in heterocyclic synthesis, enabling efficient access to fluorinated pyridine scaffolds relevant to medicinal chemistry. Its conjugated enone system facilitates nucleophilic addition and Michael-type reactions, while the carboxylic acid group supports direct derivatization or metal-mediated coupling. The compound exhibits good bench stability and clean purification profiles, making it suitable for multi-step syntheses and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.16
  • LogP   0.2122
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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