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5-Fluoro-2-hydroxynicotinaldehyde

  • CAS No. 917391-98-1

  • Cat. No. CS-0116000
  • Purity≥98%
  • MDL No.MFCD19227102

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-hydroxynicotinaldehyde|CS-0116000

Structure of 917391-98-1

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General Information

  • CAS No. 917391-98-1
  • Cat. No. CS-0116000
  • Purity ≥98%
  • MDL No. MFCD19227102
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO₂
  • Molecular Weight 141.10
  • Synonym(s) None
  • SMILES O=CC1=CC(F)=CNC1=O

Description

This electron-deficient dihydropyridine aldehyde features a fluorinated ring system that enhances reactivity in nucleophilic addition and cycloaddition processes. The ortho-aldehyde group enables direct functionalization, while the conjugated carbonyl stabilizes reaction intermediates. Bench-stable under standard conditions, it serves as a key building block for bioactive heterocycles and synthetic intermediates in medicinal chemistry.

Application

5-Fluoro-2-oxo-1,2-dihydropyridine-3-carbaldehyde serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridine derivatives. Its conjugated enone-aldehyde functionality facilitates Michael additions, Mannich reactions, and condensation processes under mild conditions. The fluorine substituent enhances metabolic stability and modulates electronic properties, making it valuable for medicinal chemistry applications. Bench-stable and amenable to standard purification methods, it functions effectively in multistep syntheses requiring precise functional group placement.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.93
  • LogP   0.3265
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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