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CS-W001157 4
Total: USD 88.00

NSC 226152

  • CAS No. 609-71-2

  • Cat. No. CS-W018547
  • Purity≥98%
  • MDL No.MFCD00010100

*For research and further manufacturing use only, not for direct human use.

NSC 226152|CS-W018547

Structure of 609-71-2

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General Information

  • CAS No. 609-71-2
  • Cat. No. CS-W018547
  • Purity ≥98%
  • MDL No. MFCD00010100
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅NO₃
  • Molecular Weight 139.11
  • Synonym(s) 2-Hydroxynicotinic acid; 2-Hydroxypyridine-3-carboxylic acid; 2-oxo-1,2-dihydropyridine-3-carboxylic acid
  • SMILES O=C(C1=CC=CNC1=O)O

Description

2-Hydroxypyridine-3-carboxylic acid may be used in chemical synthesis.

Application

2-Hydroxynicotinic acid serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling access to heterocyclic scaffolds via cyclization reactions. Its ortho-hydroxyl and carboxylic acid functionalities provide complementary reactivity for coupling, esterification, and metal coordination. The compound exhibits bench stability and facilitates straightforward purification, making it well-suited for use in multistep syntheses and API development workflows.

Synthesis

  • Route1

    References

    • Sanmartin, Carmen; Dominguez, Maria Victoria; Cordeu, Lucia; Cubedo, Elena; Garcia-Foncillas, Jesus; Font, Maria; Palop, Juan Antonio Archiv der Pharmazie, 2008 , vol. 341, # 1 p. 28 - 41
  • Route2

    References

    • US4081451 A1, ;
  • Route3

    References

    • WO2012/102580 A1, ; Page/Page column 72 ; WO 2012/102580 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.16
  • LogP   0.0731
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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