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CS-W001157 4
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2,4-Dichloro-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine

  • CAS No. 87466-23-7

  • Cat. No. CS-0456795
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine|CS-0456795

Structure of 87466-23-7

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General Information

  • CAS No. 87466-23-7
  • Cat. No. CS-0456795
  • Purity ≥98%
  • MDL No. None
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆Cl₂N₂S
  • Molecular Weight 221.11
  • Synonym(s) 8-dihydro-6H-thiopyrano[3
  • SMILES C1CC2=C(C(=NC(=N2)Cl)Cl)SC1

Synthesis

  • Route1
    • 7,8-Dihydro-6H-thiopyrano[3,2-d]pyrimidine-2,4-diol|CS-0035585
      87466-56-6
    • ~80%
    • 2,4-Dichloro-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine|CS-0456795
      87466-23-7

    References

    • Goto, Taiji; Shiina, Akiko; Murata, Takeshi; Tomii, Masato; Yamazaki, Takanori; Yoshida, Ken-Ichi; Yoshino, Toshiharu; Suzuki, Osamu; Sogawa, Yoshitaka; Mizukami, Kiyoshi; Takagi, Nana; Yoshitomi, Tomomi; Etori, Maki; Tsuchida, Hiroshi; Mikkaichi, Tsuyoshi; Nakao, Naoki; Takahashi, Mizuki; Takahashi, Hisashi; Sasaki, Shigeki Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 893 - 899
  • Route2
    • null|null
      87466-55-5
    • ~%
    • 2,4-Dichloro-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine|CS-0456795
      87466-23-7

    References

    • Ohno; Mizukoshi; Komatsu; Kunoh; Nakamura; Katoh; Nagasaka Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 10 p. 4150 - 4165
  • Route3
    • Ethyl 4-((2-ethoxy-2-oxoethyl)thio)butanoate|CS-0361527
      63449-37-6
    • ~%
    • 2,4-Dichloro-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine|CS-0456795
      87466-23-7

    References

    • CELLZOME LIMITED; LYNCH, Rosemary; CANSFIELD, Andrew David; HARDY, Daniel Paul; FEUTRILL, John Thomas; ADREGO, Rita; ELLARD, Katie; LADDUWAHETTY, Tammy Patent: WO2013/50508 A1, 2013 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.8217
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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