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CS-W001157 4
Total: USD 88.00

4,4'-(6-Chloropyrimidine-2,4-diyl)dimorpholine

  • CAS No. 10244-24-3

  • Cat. No. CS-M0292
  • Purity≥95%
  • MDL No.MFCD01873150

*For research and further manufacturing use only, not for direct human use.

4,4'-(6-Chloropyrimidine-2,4-diyl)dimorpholine|CS-M0292

Structure of 10244-24-3

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General Information

  • CAS No. 10244-24-3
  • Cat. No. CS-M0292
  • Purity ≥95%
  • MDL No. MFCD01873150
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇ClN₄O₂
  • Molecular Weight 284.75
  • Synonym(s) None
  • SMILES ClC1=CC(N2CCOCC2)=NC(N3CCOCC3)=N1

Synthesis

  • Route1
    • null|null
      110-91-8
    • In-stock
      NSC 6494|CS-W008766
      3764-01-0
    • ~92%
    • In-stock
      4,4'-(6-Chloropyrimidine-2,4-diyl)dimorpholine|CS-M0292
      10244-24-3

    References

    • NOVARTIS AG; CALIENNI, John Vincent; DE LA CRUZ, Marilyn; FLUBACHER, Dietmar; GONG, Baoqing; KAPA, Prasad Koteswara; KARPINSKI, Piotr H.; LIU, Hui; MICHEL, Pascal; MOSE, Rasmus; TESTA, Maria Caterina; WAYKOLE, Liladhar Murlidhar Patent: WO2012/44727 A2, 2012 ; Location in patent: Page/Page column 62-63 ;
  • Route2
    • null|null
      110-91-8
    • In-stock
      4-(4,6-Dichloropyrimidin-2-yl)morpholine|CS-M0291
      10397-13-4
    • ~98%
    • In-stock
      4,4'-(6-Chloropyrimidine-2,4-diyl)dimorpholine|CS-M0292
      10244-24-3

    References

    • Burger, Matthew T.; Pecchi, Sabina; Wagman, Allan; Ni, Zhi-Jie; Knapp, Mark; Hendrickson, Thomas; Atallah, Gordana; Pfister, Keith; Zhang, Yanchen; Bartulis, Sarah; Frazier, Kelly; Ng, Simon; Smith, Aaron; Verhagen, Joelle; Haznedar, Joshua; Huh, Kay; Iwanowicz, Ed; Xin, Xiaohua; Menezes, Daniel; Merritt, Hanne; Lee, Isabelle; Wiesmann, Marion; Kaufman, Susan; Crawford, Kenneth; Chin, Michael; Bussiere, Dirksen; Shoemaker, Kevin; Zaror, Isabel; Maira, Sauveur-Michel; Voliva, Charles F. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 774 - 779
  • Route3

    References

    • WO2008/98058 A1, ; Page/Page column 57-58 ; WO 2008/098058 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.72
  • LogP   0.8032
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   2

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