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CS-W001157 4
Total: USD 88.00

L-Dihydroorotic acid

  • CAS No. 5988-19-2

  • Cat. No. CS-W016211
  • Purity≥97%
  • MDL No.MFCD00085339

*For research and further manufacturing use only, not for direct human use.

L-Dihydroorotic acid|CS-W016211

Structure of 5988-19-2

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General Information

  • CAS No. 5988-19-2
  • Cat. No. CS-W016211
  • Purity ≥97%
  • MDL No. MFCD00085339
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₂O₄
  • Molecular Weight 158.11
  • Synonym(s) None
  • SMILES O=C([C@H](CC(N1)=O)NC1=O)O

Description

Intercalating into pyrimidine biosynthesis pathways, L-Dihydroorotic acid (CAS 5988-19-2) inhibits orotidine-5'-monophosphate decarboxylase activity and disrupts de novo uridine nucleotide formation in mammalian cell cultures.

Application

L-Dihydroorotic acid (CAS 5988-19-2) drives dihydroorotate dehydrogenase (DHODH) activity assays by serving as a precise enzymatic substrate. It enables real-time kinetic monitoring of DHODH function. Researchers rely on this setup to evaluate inhibitor potency in antiproliferative and immunomodulatory drug screening pipelines.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   95.5
  • LogP   -1.3309
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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