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Structure of 543739-84-0
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5-(Trifluoromethyl)-1H-pyrazole-4-carboxylic acid features a strongly electron-deficient pyrazole core paired with a potent trifluoromethyl group, enhancing metabolic stability and membrane permeability. This scaffold integrates readily into bioactive molecules, enabling efficient access to pharmaceutical candidates with improved pharmacokinetic profiles.
5-(Trifluoromethyl)-1H-pyrazole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functionalization reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid facilitates direct amidation or esterification. The compound exhibits excellent bench stability and is compatible with diverse reaction conditions, making it ideal for iterative synthesis campaigns and API development.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: