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CS-W001157 4
Total: USD 88.00

5-Iodo-2-(trifluoromethyl)pyridine

  • CAS No. 873107-98-3

  • Cat. No. CS-W022393
  • Purity≥95%
  • MDL No.MFCD11226772

*For research and further manufacturing use only, not for direct human use.

5-Iodo-2-(trifluoromethyl)pyridine|CS-W022393

Structure of 873107-98-3

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General Information

  • CAS No. 873107-98-3
  • Cat. No. CS-W022393
  • Purity ≥95%
  • MDL No. MFCD11226772
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₃IN
  • Molecular Weight None
  • Synonym(s) None
  • SMILES FC(C1=NC=C(I)C=C1)(F)F

Description

5-Iodo-2-(trifluoromethyl)pyridine features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the iodine substituent enables facile cross-coupling reactions. This pyridine scaffold integrates readily into pharmaceutical intermediates and functional materials under standard conditions.

Application

5-Iodo-2-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. The iodide group enables reliable Suzuki, Stille, and Negishi couplings, while the trifluoromethyl substituent enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with diverse functional groups make it ideal for constructing complex heterocyclic scaffolds and API intermediates in drug discovery workflows.

Synthesis

  • Route1

    References

    • WO2006/4533 A1, ; Page/Page column 25 ; WO 2006/004533 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.705
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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