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CS-W001157 4
Total: USD 88.00

4-Chloro-5-iodo-2-(trifluoromethyl)pyridine

  • CAS No. 1027818-88-7

  • Cat. No. CS-0157806
  • Purity≥97%
  • MDL No.MFCD24369746
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-5-iodo-2-(trifluoromethyl)pyridine|CS-0157806

Structure of 1027818-88-7

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Description

4-Chloro-5-iodo-2-(trifluoromethyl)pyridine features a trifluoromethyl group flanked by chlorine and iodine substituents on a pyridine core, enabling selective cross-coupling reactions. The electron-deficient aromatic framework supports palladium-catalyzed transformations, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity in medicinal chemistry applications.

Application

4-Chloro-5-iodo-2-(trifluoromethyl)pyridine serves as a versatile heterocyclic building block for Suzuki-Miyaura and Sonogashira coupling reactions, enabling efficient construction of biaryl and alkynyl scaffolds. The orthogonal reactivity of the chloro and iodo substituents allows sequential functionalization under mild conditions. Bench-stable and compatible with diverse reaction environments, it facilitates the synthesis of complex trifluoromethylated pyridine derivatives relevant to pharmaceutical and agrochemical development.

General Information

  • CAS No. 1027818-88-7
  • Cat. No. CS-0157806
  • Purity ≥97%
  • MDL No. MFCD24369746
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂ClF₃IN
  • Molecular Weight 307.44
  • Synonym(s) 4-Chloro-5-iodo-alpha,alpha,alpha-trifluoro-2-picoline
  • SMILES C1=C(C(=CN=C1C(F)(F)F)I)Cl

Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.3584
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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