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CS-W001157 4
Total: USD 88.00

4-Iodo-2-(trifluoromethyl)pyridine

  • CAS No. 590371-73-6

  • Cat. No. CS-W018675
  • Purity≥97%
  • MDL No.MFCD08234939

*For research and further manufacturing use only, not for direct human use.

4-Iodo-2-(trifluoromethyl)pyridine|CS-W018675

Structure of 590371-73-6

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General Information

  • CAS No. 590371-73-6
  • Cat. No. CS-W018675
  • Purity ≥97%
  • MDL No. MFCD08234939
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₃IN
  • Molecular Weight 272.99
  • Synonym(s) None
  • SMILES IC1=CC(=NC=C1)C(F)(F)F

Description

4-Iodo-2-(trifluoromethyl)pyridine features a trifluoromethyl group flanking a reactive iodine at the pyridine ring's 4-position, enabling efficient cross-coupling transformations. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds and functional materials under standard conditions.

Application

4-Iodo-2-(trifluoromethyl)pyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki, Stille, and Negishi reactions due to its stable iodide functionality and electron-deficient pyridine core. The trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. Its bench-stable, crystalline form facilitates handling and purification, supporting scalable synthesis of heterocyclic scaffolds and functionalized API intermediates.

Synthesis

  • Route1
    • 3-Iodo-2-(trifluoromethyl)pyridine|CS-0239484
      590371-71-4
    • ~60%
    • In-stock
      4-Iodo-2-(trifluoromethyl)pyridine|CS-W018675
      590371-73-6

    References

    • European Journal of Organic Chemistry, , # 8 p. 1559 - 1568
  • Route2
    • null|null
      368-48-9
    • ~%
    • In-stock
      4-Iodo-2-(trifluoromethyl)pyridine|CS-W018675
      590371-73-6

    References

    • European Journal of Organic Chemistry, , # 8 p. 1559 - 1568

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.705
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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