6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid

Name: 6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 871727-05-8
Cat. No. CS-W003745
Purity≥97%
MDL No.MFCD11007805

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid|CS-W003745

Structure of 871727-05-8

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 871727-05-8
Cat. No. CS-W003745
Purity ≥97%
MDL No. MFCD11007805
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₁NO₄
Molecular Weight 255.31
Synonym(s) 6-Boc-6-azaspiro[2.5]octane-1-carboxylic Acid
SMILES O=C(C1CC12CCN(C(OC(C)(C)C)=O)CC2)O

Description

6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid is a sterically encumbered spirocyclic scaffold featuring a protected amine and carboxylic acid handle, enabling direct incorporation into complex molecular architectures. This bench-stable derivative supports efficient functionalization in medicinal chemistry campaigns.

Application

6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid serves as a versatile spirocyclic building block for medicinal chemistry campaigns, enabling efficient access to constrained heterocyclic scaffolds. The Boc-protected amine and carboxylic acid functionality offer orthogonal reactivity, facilitating sequential derivatization. Bench-stable and readily purified by chromatography, it functions effectively in standard peptide coupling and cyclization protocols.

Synthesis

Route1
- In-stock
  
  871727-04-7
- ~92%
- In-stock
  
  871727-05-8
References
- Gilbert, Eric J.; Zhou, Guowei; Wong, Michael K.C.; Tong, Ling; Shankar, Bandarpalle B.; Huang, Chunli; Kelly, Joseph; Lavey, Brian J.; McCombie, Stuart W.; Chen, Lei; Rizvi, Razia; Dong, Youhao; Shu, Youheng; Kozlowski, Joseph A.; Shih, Neng-Yang; Hipkin, R. William; Gonsiorek, Waldemar; Malikzay, Asra; Lunn, Charles A.; Favreau, Len; Lundell, Daniel J. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 608 - 611
Route2
- In-stock
  
  1242268-17-2
- ~%
- In-stock
  
  871727-05-8
References
- WO2013/127269 A1, ; Page/Page column 189; 190 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 66.84
LogP 2.1082
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

871727-05-8 sigma871727-05-8 manufacturer871727-05-8 price871727-05-8 structure871727-05-8 SDSbuy 871727-05-8871727-05-8 supplier871727-05-8 uses871727-05-8 molecular weightprice of 871727-05-8871727-05-8 chemical name formula of 871727-05-8

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid

CAS No. 871727-05-8

Recommended Products