Lot numbers can be found on the outside label of a product:
(1-Boc-4-piperidinyloxy)acetic acid
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CAS No. 161948-70-5
- Cat. No. CS-W001460
- Purity≥95%
- MDL No.MFCD02178987
*For research and further manufacturing use only, not for direct human use.
Structure of 161948-70-5
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General Information
- CAS No. 161948-70-5
- Cat. No. CS-W001460
- Purity ≥95%
- MDL No. MFCD02178987
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₂₁NO₅
- Molecular Weight 259.30
- Synonym(s) None
- SMILES O=C(OC(C)(C)C)N1CCC(OCC(=O)O)CC1
Description
(1-Boc-4-piperidinyloxy)acetic acid features a protected piperidinyl ether moiety paired with a carboxylic acid handle, enabling direct conjugation in peptide and small-molecule synthesis. The Boc group ensures stability during handling and storage, while the oxygen-linked piperidine facilitates incorporation into bioactive scaffolds requiring polar, basic nitrogen centers. This derivative supports efficient derivatization under mild conditions without epimerization risk.
Application
(1-Boc-4-piperidinyloxy)acetic acid serves as a stable, bench-ready building block for the synthesis of piperidinyl ether-containing compounds. Its Boc-protected amine and carboxylic acid functionalities enable orthogonal handling in multi-step syntheses. The molecule facilitates efficient incorporation into bioactive scaffolds via standard coupling reactions and supports diverse functionalization at both the piperidine nitrogen and side chain, making it well-suited for medicinal chemistry campaigns requiring precise structural control.
Synthesis
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Route1
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79-08-3 - ~%
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In-stock
161948-70-5
References
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WO2005/61489 A1, ; Page/Page column 23-24 ; WO 2005/061489 A1
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Route2
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79-08-3
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109384-19-2
- ~95%
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In-stock
161948-70-5
References
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Kallashi, Florida; Kim, Dooseop; Kowalchick, Jennifer; Park, You Jung; Hunt, Julianne A.; Ali, Amjad; Smith, Cameron J.; Hammond, Milton L.; Pivnichny, James V.; Tong, Xinchun; Xu, Suoyu S.; Anderson, Matt S.; Chen, Ying; Eveland, Suzanne S.; Guo, Qiu; Hyland, Sheryl A.; Milot, Denise P.; Cumiskey, Anne-Marie; Latham, Melanie; Peterson, Laurence B.; Rosa, Raymond; Sparrow, Carl P.; Wright, Samuel D.; Sinclair, Peter J. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 558 - 561
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Route3
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109384-19-2
- ~%
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In-stock
161948-70-5
References
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European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 76.07
- LogP 1.4871
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 3
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Key Words
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