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CS-W001157 4
Total: USD 88.00

3-Bromo-6-fluoro-2,4-dimethylpyridine

  • CAS No. 871493-04-8

  • Cat. No. CS-0972512
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-fluoro-2,4-dimethylpyridine|CS-0972512

Structure of 871493-04-8

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General Information

  • CAS No. 871493-04-8
  • Cat. No. CS-0972512
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrFN
  • Molecular Weight 204.04
  • Synonym(s) None
  • SMILES FC=1N=C(C(Br)=C(C1)C)C

Description

3-Bromo-6-fluoro-2,4-dimethylpyridine features a sterically hindered pyridine core with complementary halogen handles, enabling selective cross-coupling reactions. The electron-deficient ring facilitates transition-metal-catalyzed transformations, while the methyl groups enhance solubility and stability under standard conditions.

Application

3-Bromo-6-fluoro-2,4-dimethylpyridine serves as a versatile building block for medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromine center facilitates Suzuki, Stille, and Negishi couplings, while the fluorine and methyl groups enhance metabolic stability and modulate electronic properties. Its bench-stable, crystalline form simplifies handling and purification, making it ideal for iterative scaffold diversification in target-oriented synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.60004
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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