6-Bromo-7-(difluoromethyl)-1,2,3,4-tetrahydroquinoline

Name: 6-Bromo-7-(difluoromethyl)-1,2,3,4-tetrahydroquinoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1936429-80-9
Cat. No. CS-0099644
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Bromo-7-(difluoromethyl)-1,2,3,4-tetrahydroquinoline|CS-0099644

Structure of 1936429-80-9

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General Information

CAS No. 1936429-80-9
Cat. No. CS-0099644
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₀BrF₂N
Molecular Weight 262.10
Synonym(s) None
SMILES FC(C1=CC2=C(C=C1Br)CCCN2)F

Description

6-Bromo-7-(difluoromethyl)-1,2,3,4-tetrahydroquinoline features a sterically accessible tetrahydroquinoline core with a bromine substituent at the 6-position and a difluoromethyl group at the 7-position. This combination imparts enhanced electron-withdrawing character and improved metabolic stability, enabling direct coupling in palladium-catalyzed cross-coupling reactions. The molecule exhibits excellent bench stability and solubility in common organic solvents, facilitating use in synthetic medicinal chemistry workflows.

Application

6-Bromo-7-(difluoromethyl)-1,2,3,4-tetrahydroquinoline serves as a versatile building block for the synthesis of functionalized heterocycles and pharmaceutical intermediates. The bromo group enables palladium-catalyzed cross-coupling reactions, while the difluoromethyl substituent imparts metabolic stability and modulates electronic properties. This scaffold exhibits excellent bench stability, tolerates diverse reaction conditions, and facilitates efficient purification—making it ideal for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 12.03
LogP 3.7448
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Tetrahydroquinoline compounds

Key Words

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6-Bromo-7-(difluoromethyl)-1,2,3,4-tetrahydroquinoline

CAS No. 1936429-80-9

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