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CS-W001157 4
Total: USD 88.00

7-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline

  • CAS No. 450-62-4

  • Cat. No. CS-0107365
  • Purity≥98%
  • MDL No.MFCD00079784

*For research and further manufacturing use only, not for direct human use.

7-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline|CS-0107365

Structure of 450-62-4

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General Information

  • CAS No. 450-62-4
  • Cat. No. CS-0107365
  • Purity ≥98%
  • MDL No. MFCD00079784
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀F₃N
  • Molecular Weight 201.19
  • Synonym(s) 1,2,3,4-Tetrahydro-7-(trifluoromethyl)quinoline
  • SMILES FC(C1=CC2=C(C=C1)CCCN2)(F)F

Description

7-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline features a trifluoromethyl group at the 7-position of a saturated quinoline core, imparting enhanced electron-withdrawing character and metabolic stability. This scaffold integrates readily into medicinal chemistry libraries, offering improved membrane permeability and resistance to oxidative degradation in bioactive molecule design.

Application

7-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline serves as a valuable heterocyclic building block in medicinal chemistry, offering enhanced metabolic stability and lipophilicity due to the trifluoromethyl group. It functions as a key scaffold for bioactive molecule synthesis, demonstrating compatibility with standard functionalization protocols including electrophilic substitution and palladium-catalyzed coupling reactions. Its bench-stable nature and predictable reactivity facilitate efficient downstream derivatization in drug discovery workflows.

Synthesis

  • Route1

    References

    • Eastman Kodak Co. Patent: US2442345 , 1945 ; Full Text Show Details Eastman Kodak Co. Patent: US2432393 , 1943 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   3.0635
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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