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CS-W001157 4
Total: USD 88.00

(2,6-Difluoro-4-formylphenyl)boronic acid

  • CAS No. 871125-93-8

  • Cat. No. CS-0175134
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2,6-Difluoro-4-formylphenyl)boronic acid|CS-0175134

Structure of 871125-93-8

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General Information

  • CAS No. 871125-93-8
  • Cat. No. CS-0175134
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BF₂O₃
  • Molecular Weight 185.92
  • Synonym(s) 2 6-DIFLUORO-4-FORMYLPHENYLBORONIC ACID&
  • SMILES FC1=C(B(O)O)C(F)=CC(C=O)=C1

Description

This boronic acid features a difluorinated aromatic core paired with an aldehyde-bearing boronate handle, enabling direct conjugation via oxime ligation. The electron-withdrawing fluorines enhance electrophilicity at the carbonyl site while maintaining bench-stable reactivity under standard conditions.

Application

(2,6-Difluoro-4-formylphenyl)boronic acid serves as a versatile building block for Suzuki-Miyaura coupling reactions, enabling the efficient construction of biaryl scaffolds under mild conditions. The ortho-fluorine substituents enhance electrophilicity at the formyl position and improve stability during purification, while the boronic acid functionality tolerates diverse reaction environments. Its compatibility with both electron-rich and electron-poor partners makes it ideal for synthesizing functionalized heterocycles and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P340-P362-P403-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.5429
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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