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5-Bromo-3-(trifluoromethyl)picolinaldehyde

  • CAS No. 1227489-83-9

  • Cat. No. CS-0187116
  • Purity≥95%
  • MDL No.MFCD16606468

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-(trifluoromethyl)picolinaldehyde|CS-0187116

Structure of 1227489-83-9

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General Information

  • CAS No. 1227489-83-9
  • Cat. No. CS-0187116
  • Purity ≥95%
  • MDL No. MFCD16606468
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃BrF₃NO
  • Molecular Weight 254.00
  • Synonym(s) 5-Bromo-3-(trifluoromethyl)-2-pyridinecarboxaldehyde
  • SMILES C1=C(C=NC(=C1C(F)(F)F)C=O)Br

Description

5-Bromo-3-(trifluoromethyl)picolinaldehyde features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the bromo substituent enables downstream cross-coupling. This aldehyde serves as a key building block in medicinal chemistry for constructing bioactive heterocycles under standard conditions.

Application

5-Bromo-3-(trifluoromethyl)picolinaldehyde serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its bromo and aldehyde functionalities. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the aldehyde facilitates condensation reactions for heterocycle synthesis. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex scaffolds in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.6754
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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