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CS-W001157 4
Total: USD 88.00

(2,3-Difluoro-4-formylphenyl)boronic acid

  • CAS No. 480424-84-8

  • Cat. No. CS-0134554
  • Purity≥97%
  • MDL No.MFCD04039907

*For research and further manufacturing use only, not for direct human use.

(2,3-Difluoro-4-formylphenyl)boronic acid|CS-0134554

Structure of 480424-84-8

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General Information

  • CAS No. 480424-84-8
  • Cat. No. CS-0134554
  • Purity ≥97%
  • MDL No. MFCD04039907
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BF₂O₃
  • Molecular Weight 185.92
  • Synonym(s) 2,3-Difluoro-4-formylphenylboronic acid
  • SMILES OB(C1=CC=C(C=O)C(F)=C1F)O

Description

This boronate moiety integrates a difluorinated aryl scaffold with a formyl handle, enabling efficient coupling in Suzuki-Miyaura transformations and facilitating downstream functionalization. The electron-deficient ring enhances reactivity while maintaining bench stability under standard conditions.

Application

(2,3-Difluoro-4-formylphenyl)boronic acid serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The formyl group provides orthogonal functionality for downstream transformations, including reductive amination or oxime formation, while the difluoro substitution enhances metabolic stability and modulates electronic properties in pharmaceutical intermediates. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses requiring functional group compatibility and predictable reactivity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.5429
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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