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CS-W001157 4
Total: USD 88.00

2,3-Difluoro-4-methylphenylboronic acid

  • CAS No. 508235-16-3

  • Cat. No. CS-W000946
  • Purity≥98%
  • MDL No.MFCD09751348

*For research and further manufacturing use only, not for direct human use.

2,3-Difluoro-4-methylphenylboronic acid|CS-W000946

Structure of 508235-16-3

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General Information

  • CAS No. 508235-16-3
  • Cat. No. CS-W000946
  • Purity ≥98%
  • MDL No. MFCD09751348
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BF₂O₂
  • Molecular Weight 171.94
  • Synonym(s) (2,3-Difluoro-4-methylphenyl)boronic acid
  • SMILES CC1=C(F)C(F)=C(B(O)O)C=C1

Description

This boronate reagent features a 2,3-difluoro-4-methylphenyl scaffold, offering enhanced stability and selective coupling efficiency in Suzuki-Miyaura reactions. The electron-deficient aryl ring enables rapid transmetalation, while the methyl group provides steric modulation for improved reaction control. Bench-stable under standard conditions, it facilitates reliable synthesis of fluorinated biaryl architectures.

Application

2,3-Difluoro-4-methylphenylboronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. Its ortho-fluorine substituents enhance stability and modulate reactivity, while the methyl group provides a handle for further functionalization. The boronic acid moiety offers excellent bench stability, predictable coupling efficiency, and compatibility with diverse reaction partners, making it well-suited for the synthesis of fluorinated biaryls and complex heterocyclic scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   -0.04698
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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