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CS-W001157 4
Total: USD 88.00

(2-(Benzyloxy)-5-fluorophenyl)boronic acid

  • CAS No. 779331-47-4

  • Cat. No. CS-W012705
  • Purity≥98%
  • MDL No.MFCD03788403

*For research and further manufacturing use only, not for direct human use.

(2-(Benzyloxy)-5-fluorophenyl)boronic acid|CS-W012705

Structure of 779331-47-4

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General Information

  • CAS No. 779331-47-4
  • Cat. No. CS-W012705
  • Purity ≥98%
  • MDL No. MFCD03788403
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₂BFO₃
  • Molecular Weight 246.04
  • Synonym(s) Boronic acid, B-[5-fluoro-2-(phenylmethoxy)phenyl]-
  • SMILES FC1=CC=C(OCC2=CC=CC=C2)C(B(O)O)=C1

Description

This boronic acid features a benzyloxy-substituted fluorophenyl scaffold, enabling efficient cross-coupling reactions under standard conditions. The electron-deficient aryl group enhances reactivity in Suzuki-Miyaura processes, while the bench-stable boronate moiety simplifies handling and storage.

Application

(2-(Benzyloxy)-5-fluorophenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The boronic acid functionality exhibits excellent bench stability and tolerates a range of functional groups, facilitating the synthesis of substituted biaryls and complex heterocyclic scaffolds. Its benzyloxy and fluorine substituents provide orthogonal reactivity handles and enhanced metabolic stability, making it particularly valuable in medicinal chemistry and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   1.0845
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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