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CS-W001157 4
Total: USD 88.00

(2-Fluoro-5-hydroxyphenyl)boronic acid

  • CAS No. 1150114-52-5

  • Cat. No. CS-0043940
  • Purity≥95%
  • MDL No.MFCD11855845

*For research and further manufacturing use only, not for direct human use.

(2-Fluoro-5-hydroxyphenyl)boronic acid|CS-0043940

Structure of 1150114-52-5

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General Information

  • CAS No. 1150114-52-5
  • Cat. No. CS-0043940
  • Purity ≥95%
  • MDL No. MFCD11855845
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BFO₃
  • Molecular Weight 155.92
  • Synonym(s) 2-Fluoro-5-hydroxyphenylboronic acid
  • SMILES OC1=CC=C(F)C(B(O)O)=C1

Description

This boronic acid features a fluorinated aryl ring paired with a hydroxyl group, enabling selective functionalization in cross-coupling reactions. The ortho-fluoro substitution enhances stability and modulates reactivity, while the pendant hydroxyl facilitates solubility and downstream derivatization. A bench-stable reagent for constructing complex phenolic architectures under standard conditions.

Application

(2-Fluoro-5-hydroxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The ortho-fluoro and phenolic hydroxyl groups provide enhanced reactivity and directing effects, while the boronic acid moiety offers good bench stability and compatibility with diverse functional groups. This compound facilitates rapid access to fluorinated aromatic systems relevant in medicinal chemistry and materials science.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.7889
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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