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CS-W001157 4
Total: USD 88.00

(2-Fluoro-4-formylphenyl)boronic acid

  • CAS No. 871126-22-6

  • Cat. No. CS-W014301
  • Purity≥97%
  • MDL No.MFCD07367058

*For research and further manufacturing use only, not for direct human use.

(2-Fluoro-4-formylphenyl)boronic acid|CS-W014301

Structure of 871126-22-6

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General Information

  • CAS No. 871126-22-6
  • Cat. No. CS-W014301
  • Purity ≥97%
  • MDL No. MFCD07367058
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BFO₃
  • Molecular Weight 167.93
  • Synonym(s) 2-Fluoro-4-formylphenylboronic acid
  • SMILES O=CC1=CC=C(B(O)O)C(F)=C1

Description

This boronic acid features a fluorinated aryl scaffold with a formyl group positioned ortho to the boronic acid moiety, enabling selective coupling in Suzuki-Miyaura reactions. The electron-withdrawing fluorine enhances reactivity while maintaining bench stability, and the formyl functionality allows for downstream derivatization via condensation or reduction.

Application

(2-Fluoro-4-formylphenyl)boronic acid serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The ortho-fluoro substituent enhances regioselectivity in subsequent transformations, while the formyl group provides a handle for derivatization via condensation or reductive amination. Bench-stable and compatible with standard Suzuki-Miyaura coupling conditions, it facilitates rapid access to functionalized aromatic scaffolds relevant to medicinal chemistry and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.682
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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