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CS-W001157 4
Total: USD 88.00

(2-Fluoro-4-(hydroxymethyl)phenyl)boronic acid

  • CAS No. 1331945-14-2

  • Cat. No. CS-0063797
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2-Fluoro-4-(hydroxymethyl)phenyl)boronic acid|CS-0063797

Structure of 1331945-14-2

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General Information

  • CAS No. 1331945-14-2
  • Cat. No. CS-0063797
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BFO₃
  • Molecular Weight 169.95
  • Synonym(s) [2-Fluoro-4-(hydroxyMethyl)phenyl]boronic acid
  • SMILES OCC1=CC=C(B(O)O)C(F)=C1

Description

This boronic acid features a fluorinated aryl ring paired with a hydroxymethyl-bearing boronate group, enabling efficient Suzuki-Miyaura coupling under standard conditions. The ortho-fluoro substituent enhances reactivity and metabolic stability, while the hydroxymethyl handle facilitates downstream functionalization. Bench-stable and moisture-tolerant, it integrates seamlessly into complex molecule synthesis workflows.

Application

(2-Fluoro-4-(hydroxymethyl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The hydroxymethyl group provides a handle for downstream functionalization, while the boronic acid moiety exhibits excellent bench stability and compatibility with diverse reaction conditions. Its ortho-fluorine substituent enhances reactivity and facilitates selective transformations, making it a practical choice for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -1.0022
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

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