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CS-W001157 4
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2-(2,6-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 863868-37-5

  • Cat. No. CS-W000986
  • Purity≥95%
  • MDL No.MFCD09801043

*For research and further manufacturing use only, not for direct human use.

2-(2,6-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-W000986

Structure of 863868-37-5

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General Information

  • CAS No. 863868-37-5
  • Cat. No. CS-W000986
  • Purity ≥95%
  • MDL No. MFCD09801043
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅BF₂O₂
  • Molecular Weight 240.05
  • Synonym(s) 2,6-DifluoroBenzeneBoronicacid,pinacolester
  • SMILES CC1(C)OB(OC1(C)C)c1c(F)cccc1F

Description

This boronate ester features a 2,6-difluorophenyl group attached to a tetramethyl-1,3,2-dioxaborolane scaffold, delivering enhanced stability and reactivity in cross-coupling processes. The electron-withdrawing difluoro substitution improves coupling efficiency while maintaining bench-stable handling characteristics under standard conditions.

Application

2-(2,6-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. Its ortho-difluorophenyl moiety enables efficient coupling with aryl halides and triflates, offering enhanced reactivity and metabolic stability in complex molecule synthesis. The tetramethyl-substituted dioxaborolane ring ensures high chemical stability, minimal protodeboronation, and straightforward purification—ideal for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.264
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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