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CS-W001157 4
Total: USD 88.00

Fmoc-HoPro-OH

  • CAS No. 86069-86-5

  • Cat. No. CS-W013906
  • Purity≥98%
  • MDL No.MFCD00235898

*For research and further manufacturing use only, not for direct human use.

Fmoc-HoPro-OH|CS-W013906

Structure of 86069-86-5

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General Information

  • CAS No. 86069-86-5
  • Cat. No. CS-W013906
  • Purity ≥98%
  • MDL No. MFCD00235898
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₁NO₄
  • Molecular Weight 351.40
  • Synonym(s) None
  • SMILES O=C(O)[C@H]1N(C(OCC2C3=CC=CC=C3C4=CC=CC=C24)=O)CCCC1

Description

Fmoc-HoPro-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a hydroxylated proline moiety. This modified building block integrates seamlessly into peptide synthesis workflows, enabling site-specific incorporation of hydroxyproline residues to enhance structural stability and bioactivity in target peptides.

Application

Fmoc-HoPro-OH serves as a key building block in peptide synthesis, enabling the incorporation of hydroxyproline residues with high fidelity. The Fmoc group provides orthogonal protection for the α-amino function, allowing for efficient stepwise chain elongation under standard solid-phase conditions. Its hydroxylated side chain facilitates hydrogen bonding and structural stabilization in bioactive peptides, particularly relevant in collagen mimetics and conformationally constrained sequences. The compound exhibits excellent bench stability, solubility in common organic solvents, and compatibility with standard coupling reagents.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   3.8746
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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