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CS-W001157 4
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1-Boc-piperidine-2-carboxylic acid

  • CAS No. 98303-20-9

  • Cat. No. CS-B0409
  • Purity≥97%
  • MDL No.MFCD01862877

*For research and further manufacturing use only, not for direct human use.

1-Boc-piperidine-2-carboxylic acid|CS-B0409

Structure of 98303-20-9

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General Information

  • CAS No. 98303-20-9
  • Cat. No. CS-B0409
  • Purity ≥97%
  • MDL No. MFCD01862877
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₄
  • Molecular Weight 229.27
  • Synonym(s) Boc-DL-Pip-OH
  • SMILES O=C(OC(C)(C)C)N(CCCC1)C1C(O)=O

Description

1-Boc-piperidine-2-carboxylic acid features a protected piperidine scaffold ideal for peptide and heterocyclic synthesis. The Boc group enables straightforward deprotection under mild acidic conditions, while the carboxylic acid moiety supports direct coupling reactions. This derivative offers enhanced stability and solubility in organic solvents, streamlining incorporation into complex molecular architectures.

Application

1-Boc-piperidine-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of piperidine-based scaffolds through standard deprotection and coupling protocols. Its Boc group provides excellent bench stability and compatibility with diverse reaction conditions, while the carboxylic acid functionality facilitates efficient amide bond formation and peptide coupling. This compound functions reliably in multi-step syntheses requiring controlled functionalization and orthogonal protection strategies.

Synthesis

  • Route1
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      4043-87-2
    • ~99%
    • In-stock
      1-Boc-piperidine-2-carboxylic acid|CS-B0409
      98303-20-9

    References

    • Khalil, Ehab M.; Subasinghe, Nalin L.; Johnson, Rodney L. Tetrahedron Letters, 1996 , vol. 37, # 20 p. 3441 - 3444
  • Route2

    References

    • Schmidt, Andrea-Katharina C.; Stark, Christian B. W. Organic Letters, 2011 , vol. 13, # 16 p. 4164 - 4167
  • Route3
    • In-stock
      N-((tert-Butoxycarbonyl)oxy)benzimidoyl cyanide|CS-W012697
      58632-95-4
    • null|null
      4043-87-2
    • ~73%
    • In-stock
      1-Boc-piperidine-2-carboxylic acid|CS-B0409
      98303-20-9

    References

    • Ho, Bin; Venkatarangan, Prabha M.; Cruse, Sharon F.; Hinko, Christine N.; Andersen, Peter H.; Crider, Albert M.; Adloo, Ahmad A.; Roane, David S.; Stables, James P. European Journal of Medicinal Chemistry, 1998 , vol. 33, # 1 p. 23 - 31

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.8606
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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