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CS-W001157 4
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6-Chloro-N-methylpicolinamide

  • CAS No. 845306-04-9

  • Cat. No. CS-0151056
  • Purity≥98%
  • MDL No.MFCD09862945

*For research and further manufacturing use only, not for direct human use.

6-Chloro-N-methylpicolinamide|CS-0151056

Structure of 845306-04-9

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General Information

  • CAS No. 845306-04-9
  • Cat. No. CS-0151056
  • Purity ≥98%
  • MDL No. MFCD09862945
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClN₂O
  • Molecular Weight 170.60
  • Synonym(s) 6-chloro-N-methylpyridine-2-carboxamide
  • SMILES CNC(=O)C1=NC(=CC=C1)Cl

Description

6-Chloro-N-methylpicolinamide features a chlorinated pyridine ring paired with a methylated amide group, delivering enhanced electron-withdrawing character and improved solubility. This combination enables efficient integration into pharmaceutical intermediates and synthetic scaffolds under standard conditions.

Application

6-Chloro-N-methylpicolinamide serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through direct functionalization at the C6 position. Its chloro group facilitates palladium-catalyzed cross-coupling reactions, while the N-methylamide moiety provides enhanced metabolic stability and favorable solubility profiles. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, facilitating straightforward purification and integration into complex molecule synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.99
  • LogP   1.0946
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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