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CS-W001157 4
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4-Chloro-N-methylpicolinamide

  • CAS No. 220000-87-3

  • Cat. No. CS-M2758
  • Purity≥98%
  • MDL No.MFCD02185921

*For research and further manufacturing use only, not for direct human use.

4-Chloro-N-methylpicolinamide|CS-M2758

Structure of 220000-87-3

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General Information

  • CAS No. 220000-87-3
  • Cat. No. CS-M2758
  • Purity ≥98%
  • MDL No. MFCD02185921
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClN₂O
  • Molecular Weight 170.60
  • Synonym(s) None
  • SMILES ClC1=CC(C(NC)=O)=NC=C1

Description

4-Chloro-N-methyl-2-pyridinecarboxamide features a chlorinated pyridine core with a methylated amide group, delivering enhanced metabolic stability and improved membrane permeability. This configuration supports efficient integration into bioactive scaffolds for medicinal chemistry applications, particularly in kinase inhibitor development and CNS-targeted drug discovery.

Application

4-Chloro-N-methyl-2-pyridinecarboxamide serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. Its chloro group facilitates nucleophilic substitution and palladium-catalyzed coupling reactions, while the N-methyl amide provides stability and favorable solubility. This compound demonstrates excellent bench stability and functional group tolerance, making it well-suited for iterative synthesis and scale-up in API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.99
  • LogP   1.0946
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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