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CS-W001157 4
Total: USD 88.00

3-Fluoro-4-aminophenol

  • CAS No. 399-95-1

  • Cat. No. CS-M1784
  • Purity≥95%
  • MDL No.MFCD00077452

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-4-aminophenol|CS-M1784

Structure of 399-95-1

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General Information

  • CAS No. 399-95-1
  • Cat. No. CS-M1784
  • Purity ≥95%
  • MDL No. MFCD00077452
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO
  • Molecular Weight 127.12
  • Synonym(s) 4-Amino-3-fluorophenol
  • SMILES OC1=CC(F)=C(N)C=C1

Description

3-Fluoro-4-aminophenol features a fluorine atom at the meta position relative to an electron-rich amino group, creating a unique electronic profile ideal for targeted conjugation. This bench-stable phenolic scaffold integrates seamlessly into bioconjugates and pharmaceutical intermediates, where regioselective reactivity enhances synthetic efficiency in complex molecule assembly.

Application

3-Fluoro-4-aminophenol serves as a key building block in the synthesis of fluorinated aromatic amines and heterocyclic scaffolds. Its dual functionality enables direct coupling reactions, including Suzuki-Miyaura and Ullmann-type transformations, while maintaining bench stability and ease of purification. The ortho-fluoro and para-amino groups offer complementary reactivity for sequential functionalization, making it a valuable intermediate in medicinal chemistry and agrochemical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.1135
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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