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CS-W001157 4
Total: USD 88.00

4-Chloropyridine-2-carboxamide

  • CAS No. 99586-65-9

  • Cat. No. CS-W002746
  • Purity≥95%
  • MDL No.MFCD01085339

*For research and further manufacturing use only, not for direct human use.

4-Chloropyridine-2-carboxamide|CS-W002746

Structure of 99586-65-9

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General Information

  • CAS No. 99586-65-9
  • Cat. No. CS-W002746
  • Purity ≥95%
  • MDL No. MFCD01085339
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClN₂O
  • Molecular Weight 156.57
  • Synonym(s) 4-Chloropicolinamide; 4-Chloropyridine-2-carboxamide
  • SMILES ClC1=CC(C(N)=O)=NC=C1

Description

Trimethylsilyl isothiocyanate is used as derivatizing reagent during the synthesis of amino acid thiohydantoins. It participates in ring opening reaction of N-substituted aziridines and cyclohexene oxide.

Synthesis

  • Route1

    References

    • Bristol-Myers Squibb Company Patent: US2007/78140 A1, 2007 ; Location in patent: Page/Page column 25 ; US 20070078140 A1
  • Route2
    • 4-Chloro-pyridine-2-carboxylic acid methyl ester Sorafenib Impurity|CS-0181541
      24484-93-3
    • ~85%
    • In-stock
      4-Chloropyridine-2-carboxamide|CS-W002746
      99586-65-9

    References

    • Vera, Matthew D.; Lundquist IV, Joseph T.; Chengalvala, Murty V.; Cottom, Joshua E.; Feingold, Irene B.; Garrick, Lloyd M.; Green, Daniel M.; Hauze, Diane B.; Mann, Charles W.; Mehlmann, John F.; Rogers, John F.; Shanno, Linda; Wrobel, Jay E.; Pelletier, Jeffrey C. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2512 - 2515
  • Route3
    • null|null
      53750-66-6
    • ~%
    • In-stock
      4-Chloropyridine-2-carboxamide|CS-W002746
      99586-65-9

    References

    • Heterocycles, , vol. 53, # 4 p. 797 - 804

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.98
  • LogP   0.8339
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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