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CS-W001157 4
Total: USD 88.00

2-Chloropyridine-3,4-diamine

  • CAS No. 39217-08-8

  • Cat. No. CS-D0776
  • Purity≥98%
  • MDL No.MFCD07363739

*For research and further manufacturing use only, not for direct human use.

2-Chloropyridine-3,4-diamine|CS-D0776

Structure of 39217-08-8

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General Information

  • CAS No. 39217-08-8
  • Cat. No. CS-D0776
  • Purity ≥98%
  • MDL No. MFCD07363739
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆ClN₃
  • Molecular Weight 143.57
  • Synonym(s) NSC 143160; 2-Chloropyridin-3,4-diamine
  • SMILES NC1=C(N)C(Cl)=NC=C1

Description

2-Chloropyridine-3,4-diamine features a pyridine core with strategically positioned chlorine and diamine functionalities, enabling direct incorporation into heterocyclic scaffolds. This electron-rich, bench-stable compound serves as a key building block for pharmaceutical intermediates and functional materials, facilitating efficient coupling reactions under mild conditions.

Application

2-Chloropyridine-3,4-diamine serves as a versatile building block in medicinal chemistry, enabling rapid access to substituted pyridine scaffolds via palladium-catalyzed cross-coupling reactions. Its dual amine functionalities and chlorine handle offer orthogonal reactivity for sequential derivatization, while demonstrating excellent bench stability and compatibility with standard purification protocols.

Synthesis

  • Route1

    References

    • UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. Patent: WO2007/47793 A2, 2007 ; Location in patent: Page/Page column 87 ;
  • Route2
    • null|null
      1312105-99-9
    • ~91%
    • In-stock
      2-Chloropyridine-3,4-diamine|CS-D0776
      39217-08-8

    References

    • Mineno, Tomoko; Kansui, Hisao; Yoshimitsu, Hitoshi Tetrahedron Letters, 2011 , vol. 52, # 24 p. 3131 - 3132
  • Route3

    References

    • Dvorakova, Hana; Holy, Antonin; Votruba, Ivan; Masojidkova, Milena Collection of Czechoslovak Chemical Communications, 1993 , vol. 58, # 3 p. 629 - 648

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H317-H319
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   64.93
  • LogP   0.8994
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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