Lot numbers can be found on the outside label of a product:
6-Chloro-3,4-pyridinediamine
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CAS No. 89182-17-2
- Cat. No. CS-W003135
- Purity≥96%
- MDL No.MFCD04037269
*For research and further manufacturing use only, not for direct human use.
Structure of 89182-17-2
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General Information
- CAS No. 89182-17-2
- Cat. No. CS-W003135
- Purity ≥96%
- MDL No. MFCD04037269
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₆ClN₃
- Molecular Weight None
- Synonym(s) 6-Chloropyridine-3,4-diamine
- SMILES ClC1=NC=C(N)C(N)=C1
Description
6-Chloro-3,4-pyridinediamine is a bench-stable, electron-deficient heterocyclic diamine featuring a chlorinated pyridine core. This compound integrates readily into pharmaceutical scaffolds and serves as a key intermediate in the synthesis of kinase inhibitors and antiviral agents.
Application
6-Chloro-3,4-pyridinediamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and cyclization reactions. Its dual amine functionalities exhibit excellent regioselectivity in nucleophilic substitution and palladium-catalyzed cross-coupling processes, while the chlorine atom provides a reliable handle for further functionalization. The compound demonstrates good bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis of kinase inhibitors and other pharmaceutical intermediates.
Synthesis
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Route1
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In-stock
2604-39-9 - ~97%
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In-stock
89182-17-2
References
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F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James John; MATHIEU, Simon; RUDOLPH, Joachim; LEE, Wendy Patent: WO2013/92940 A1, 2013 ; Location in patent: Page/Page column 54 ;
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Route2
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7647-01-0 -
In-stock
1681-37-4 - ~%
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In-stock
89182-17-2
References
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Chemische Berichte, , vol. 57, p. 1183
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Route3
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7647-01-0
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In-stock
2604-39-9
- ~%
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In-stock
89182-17-2
References
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Roczniki Chemii, , vol. 30, p. 1139,1144 Chem.Abstr., , p. 12089
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Safety Information
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 64.93
- LogP 0.8994
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 0
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