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CS-W001157 4
Total: USD 88.00

1-Boc-Nipecotic acid

  • CAS No. 84358-12-3

  • Cat. No. CS-W019952
  • Purity≥97%
  • MDL No.MFCD00673775

*For research and further manufacturing use only, not for direct human use.

1-Boc-Nipecotic acid|CS-W019952

Structure of 84358-12-3

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General Information

  • CAS No. 84358-12-3
  • Cat. No. CS-W019952
  • Purity ≥97%
  • MDL No. MFCD00673775
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₄
  • Molecular Weight None
  • Synonym(s) 1-Boc-Piperidine-3-carboxylic acid
  • SMILES O=C(N1CC(C(O)=O)CCC1)OC(C)(C)C

Description

1-Boc-Nipecotic acid is a bench-stable, moisture-tolerant building block featuring a protected pyrrolidine ring with a Boc-activated carboxylic acid. This derivative enables direct incorporation into peptide conjugates and heterocyclic scaffolds under standard coupling conditions, offering reliable reactivity for synthetic medicinal chemistry applications.

Application

1-Boc-Nipecotic acid serves as a stable, bench-ready building block for the synthesis of pyrrolidine-based scaffolds in medicinal chemistry. Its N-Boc protection ensures compatibility with diverse coupling reactions and functional group manipulations. The molecule facilitates efficient access to biologically relevant heterocycles through straightforward deprotection and cyclization protocols, enabling rapid exploration of peptidomimetic and pharmacophore libraries.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.7181
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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